Trodelvy® (sacituzumab govitecan-hziy)
Can my other medicines interact with TRODELVY?
Gilead Sciences, Inc. is providing this letter in response to your unsolicited request for medical information. It is not promotional. It is intended for a US audience 18 years or older.
Gilead Sciences, Inc. is providing this letter in response to your unsolicited request for medical information. It is not promotional. It is intended for a US audience 18 years or older.
TRODELVY® (sacituzumab govitecan-hziy)
Can my other medicines interact with TRODELVY?
This information is provided in response to your question. It is not treatment advice on how to use TRODELVY. Please discuss this question and others you have about your medical condition or treatment with your healthcare provider.
Download the TRODELVY Patient Information for more details, including approved use(s) and important warnings: https://www.gilead.com/-/media/files/pdfs/medicines/oncology/trodelvy/trodelvy_patient_pi.pdf
The short answer1
| Taking TRODELVY together with medicines that can affect a protein called uridine diphosphate-glucuronosyl transferase 1A1 (UGT1A1) should be avoided. It is possible that taking these medicines with TRODEVY might affect how TRODELVY works or might increase side effects. | |
| Before receiving TRODELVY, tell your healthcare provider about all of your medical conditions and the medicines that you are currently taking, including over the counter medicines, vitamins and herbal supplements. Your healthcare provider can tell you if it is safe to take TRODELVY with other medicines. | |
What important information I should know about TRODELVY?1
Some medicines have important warnings that are designed to alert you of serious or life-threatening risks that come with taking the medicine.
TRODELVY has an important warning for: Severe diarrhea and severe or life- threatening low white blood cell count (neutropenia) as early as the first treatment cycle.
Your healthcare provider should check your blood cell counts during treatment. You may receive a medicine in the first cycle of treatment if you have an increased risk for developing low white blood cell count with a fever, also known as febrile neutropenia.
Your healthcare provider should monitor you for diarrhea during treatment with TRODELVY and check to see if it is caused by an infection. You may receive a medicine to help control your diarrhea.
If your white blood cell count is too low or your diarrhea is severe and cannot be controlled with medicines, your healthcare provider may lower your dose of TRODELVY, delay your treatment, or permanently stop treatment.
Who is TRODELVY for?1
TRODELVY is a prescription medicine used to treat adults with:
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TRODELVY may be used: | ||
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TRODELVY may be used: | ||
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It is not known if TRODELVY is safe and effective in people with moderate or severe liver problems or in children. | ||
How might my other medicines interact with TRODELVY?1
| Certain medicines when taken together can react with each other in ways that can change how they work or cause side effects. When this happens, it is known as a drug-drug interaction.
Taking TRODELVY together with medicines that can affect a protein called UGT1A1 should be avoided. It is possible that taking these medicines with TRODEVY might affect how TRODELVY works or might increase side effects.
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| If you have questions about how TRODELVY might interact with any of your other medicines including over the counter medicines, vitamins, herbal supplements or specific foods please ask your health care provider.
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| Before receiving TRODELVY, tell your healthcare provider about all of your medical conditions and the medicines that you are currently taking, including over the counter medicines, vitamins and herbal supplements. Your healthcare provider can tell you if it is safe to take TRODELVY with other medicines. |
What should I know before starting TRODELVY?1
Before receiving TRODELVY, tell your healthcare provider about all of your medical conditions, including if you have been told that you carry a gene for uridine diphosphate-glucuronosyl transferase 1A1 (UGT1A1)*28. People who carry this gene have an increased risk of getting side effects with TRODELVY, especially low white blood cell counts, a fever while your white blood cell count is low, and low red blood cell counts.
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Certain medicines may affect the way TRODELVY works.
Glossary
- Diarrhea: loose or watery stools
- Endocrine hormone therapy: a type of medicine that works by blocking or changing hormones in your body. It is often used to treat certain cancers, like some breast cancers, that rely on hormones to grow
- Febrile Neutropenia: a fever while a person has low levels of neutrophils, which may indicate an infection
- Hormone receptor (HR): a hormone is a substance made by a gland in your body. A receptor is a protein found inside or on the surface of a cell. When hormones attach (bind) to specific receptors, it causes changes within the cell. There are 2 types of hormone receptors, estrogen and progesterone
- Human epidermal growth factor receptor (HER2): HER2 is a protein that can affect cell growth. A receptor is a protein found inside or on the surface of a cell. When proteins attach (bind) to specific receptors, it causes changes within the cell
- Metastatic: spread of cancer from the place where it started to other parts of the body
- Neutropenia: low levels of neutrophils, a type of white blood cell
- Triple negative breast cancer (TNBC): a type of breast cancer that does not use hormones or HER2 protein to grow
- Uridine diphosphate-glucuronosyl transferase 1A1 (UGT1A1): a protein involved in removal of certain types of waste in the body and also medicines
- White blood cells: part of your immune system that help protect you from infections, germs, and other harmful invaders. A low number can reduce your ability to fight infections
References
More information about TRODELVY
If you would like more detailed information about TRODELVY, please visit:
https://www.gilead.com/-/media/files/pdfs/medicines/oncology/trodelvy/trodelvy_pi.pdf
This is the US FDA-approved Prescribing Information, including the Patient Labeling, for TRODELVY. It will tell you about the uses, warnings, and other important safety information about TRODELVY.
Important note
Gilead Sciences, Inc. is providing this letter in response to your unsolicited request for medical information. Some of the information included in this letter may not be covered in the US FDA- approved Prescribing Information for TRODELVY. Gilead Sciences, Inc. does not intend this letter to be used as medical advice and does not promote use of TRODELVY in a way that has not been approved by the FDA. Please discuss this question and others you may have about your medical condition or treatment with your healthcare provider.
Follow-Up
For any additional questions, please contact Trodelvy Medical Information at:
☎1‐888-983-4668 or https://www.patient.askgileadmedical.com/
Reporting side effects
Please report all adverse events to:
Gilead Global Patient Safety ☎ 1-800-445-3235, option 3 or
www.gilead.com/utility/contact/report-an-adverse-event
FDA MedWatch Program by ☎ 1-800-FDA-1088 or MedWatch, FDA, 5600 Fishers Ln, Rockville, MD 20852 or www.accessdata.fda.gov/scripts/medwatch
Data Privacy
The Medical Information service at Gilead Sciences may collect, store, and use your personal information to provide a response to your medical request. We may share your information with other Gilead Sciences colleagues to ensure that your request is addressed appropriately. If you report an adverse event or concern about the quality of a Gilead or Kite product, we will need to use the information you have given us in order to meet our regulatory requirements in relation to the safety of our medicines.
It may be necessary for us to share your information with Gilead’s affiliates, business partners, service providers, and regulatory authorities located in countries besides your own. Gilead Sciences has implemented measures to protect the personal information you provide. Please see the Gilead Privacy Statement (www.gilead.com/privacy-statements) for more information about how Gilead handles your personal information and your rights. If you have any further questions about the use of your personal information, please contact privacy@gilead.com.
TRODELVY GILEAD, and the GILEAD logo are registered trademarks of Gilead Sciences, Inc., or its related companies.
© 2025 Gilead Sciences, Inc.
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Do you want to report a side effect or other concern about a Gilead medicine?
Report side effects
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FDA MedWatch
To report a side effect or product quality concern directly to the U.S. Food and Drug Administration (FDA), please call 1-800-FDA-1088 or email www.fda.gov/MedWatch.
You may also contact the U.S. Food and Drug Administration (FDA) directly to report adverse events or product quality concerns at 1-800-FDA-1088 or www.fda.gov/MedWatch.